Cirrose e Complicações 2018
The natural history of cirrhosis is characterised by an asymptomatic compensated phase followed by a decompensated
phase, marked by the development of overt clinical signs, the
most frequent of which are ascites, bleeding, encephalopathy,
and jaundice. The following Clinical Practice Guidelines (CPGs)
represent the first CPGs on the management of decompensated
cirrhosis. In this context, the panel of experts, having emphasised the importance of initiating aetiologic treatment for any
degree of hepatic disease at the earliest possible stage, extended
its work to all the complications of cirrhosis, which had not
been covered by the European Association for the Study of the
Liver guidelines, namely: ascites, refractory ascites, hyponatremia, gastrointestinal bleeding, bacterial infections, acute kidney injury, hepatorenal syndrome, acute-on-chronic liver
failure, relative adrenal failure, cirrhotic cardiomyopathy, hepatopulmonary syndrome, and porto-pulmonary hypertension.
The panel of experts, produced these GPGs using evidence from
PubMed and Cochrane database searches providing up to date
guidance on the management of decompensated cirrhosis with
the only purpose of improving clinical practice.
2018 European Association for the Study of the Liver. Published by
Elsevier B.V. All rights reserved.