Outras Publicações

2022

Cirrose e Complicações

Infeção

Prevalence and Therapeutic Management of Infections by Multi-Drug-Resistant Organisms (MDROs) in Patients with Liver Cirrhosis: A Narrative Review.
Onorato L, Monari C, Capuano S, et al.
Antibiotics (Basel). 2022 Feb 11;11(2):232.
doi: 10.3390/antibiotics11020232.
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Coagulação e Trombose

Incidence and prevalence of venous thromboembolism in chronic liver disease: A systematic review and meta-analysis.
Subhani M, Sheth A, Ahmed J, et al.
Thromb Res. 2022 Jul;215:19-29.
doi: 10.1016/j.thromres.2022.05.004.
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Disfunção hepática e ACLF

Acute-on-chronic liver failure (ACLF) in 2022: have novel treatment paradigms already arrived?
Abbas N, Rajoriya N, Elsharkawy AM, et al.
Expert Rev Gastroenterol Hepatol. 2022 Jul;16(7):639-652.
doi: 10.1080/17474124.2022.2097070.
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Outros

Ann Hepatol, AoH, APEF

Position statement on the use of albumin in liver cirrhosis.
Castro-Narro G, Moctezuma-Velázquez C, Male-Velázquez R, et al.
Ann Hepatol. 2022 Jul-Aug;27(4):100708.
doi: 10.1016/j.aohep.2022.100708.
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Nature Reviews Disease Primers, APEF

Erectile dysfunction in cirrhosis: Its prevalence and risk factors
Yafi FA, Jenkins L, Albersen M, et al.
Nat Rev Dis Primers. 2016 Feb 4;2:16003.
doi: 10.1038/nrdp.2016.3.
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Liver International, APEF

Non-selective beta-blockers in patients with ascites: The complex interplay among the liver, kidney and heart
Téllez L, Albillos A.
Liver Int. 2022 Apr;42(4):749-761.
doi: 10.1111/liv.15166.
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Hipertensão Portal

J Clin Exp Hepatol, Clinical and Experimental Hepatology, APEF

Management of Portal Hypertension.
Kulkarni AV, Rabiee A, Mohanty A.
J Clin Exp Hepatol. 2022 Jul-Aug;12(4):1184-1199.
doi: 10.1016/j.jceh.2022.03.002.
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Clin Gastroenterol Hepatol, CGH, APEF

Advancing Liver Therapeutic Approaches (ALTA) Consortium. North American Practice-Based Recommendations for Transjugular Intrahepatic Portosystemic Shunts in Portal Hypertension.
Boike JR, Thornburg BG, Asrani SK, et al.
Clin Gastroenterol Hepatol. 2022 Aug;20(8):1636-1662.e36.
doi: 10.1016/j.cgh.2021.07.018.
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Liver International, APEF

Update on the management of gastric varices.
Luo X, Hernández-Gea V.
Liver Int. 2022 Jun;42(6):1250-1258.
doi: 10.1111/liv.15181.
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Carcinoma Hepatocelular e Colangiocarcinoma

journal of hepatology, apef

BCLC strategy for prognosis prediction and treatment recommendation: The 2022 update.
Reig M, Forner A, Rimola J, et al.
J Hepatol. 2022 Mar;76(3):681-693.
doi: 10.1016/j.jhep.2021.11.018.
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Hepatocellular Carcinoma in Patients With Nonalcoholic Fatty Liver Disease: A Systematic Review, Meta-analysis, and Meta-regression.
Orci LA, Sanduzzi-Zamparelli M, Caballol B, et al.
Clin Gastroenterol Hepatol. 2022 Feb;20(2):283-292.e10.
doi: 10.1016/j.cgh.2021.05.002.
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journal of hepatology, apef

Cholangiocarcinoma landscape in Europe: Diagnostic, prognostic and therapeutic insights from the ENSCCA Registry.
Izquierdo-Sanchez L, Lamarca A, La Casta A, Buettner S, et al.
J Hepatol. 2022 May;76(5):1109-1121.
doi: 10.1016/j.jhep.2021.12.010.
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Fígado Gordo Não Alcoólico

Gastroenterology, Gastro, APEF

AGA Clinical Practice Update: Diagnosis and Management of Nonalcoholic Fatty Liver Disease in Lean Individuals: Expert Review.
Long MT, Noureddin M, Lim JK.
Gastroenterology. 2022 Jul 13:S0016-5085(22)00628-X.
doi: 10.1053/j.gastro.2022.06.023.
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Gastroenterology, Gastro, APEF

Nonalcoholic Fatty Liver Disease and the Gut-Liver Axis: Exploring an Undernutrition Perspective.
Bauer KC, Littlejohn PT, Ayala V, et al.
Gastroenterology. 2022 Jun;162(7):1858-1875.e2.
doi: 10.1053/j.gastro.2022.01.058.
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Quality standards for the management of non-alcoholic fatty liver disease (NAFLD): consensus recommendations from the British Association for the Study of the Liver and British Society of Gastroenterology NAFLD Special Interest Group.
McPherson S, Armstrong MJ, Cobbold JF, et al.
Lancet Gastroenterol Hepatol. 2022 Aug;7(8):755-769.
doi: 10.1016/S2468-1253(22)00061-9.
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Clin Gastroenterol Hepatol, CGH, APEF

Waist Circumference and Insulin Resistance Are the Most Predictive Metabolic Factors for Steatosis and Fibrosis.
Claypool K, Long MT, Patel CJ.
Clin Gastroenterol Hepatol. 2022 Jun 6:S1542-3565(22)00532-8.
doi: 10.1016/j.cgh.2022.05.021.
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Hepatol Commun, Hepatology Communications, APEF

Favorable impact of long-term SGLT2 inhibitor for NAFLD complicated by diabetes mellitus: A 5-year follow-up study.
Akuta N, Kawamura Y, Fujiyama S, et al.
Hepatol Commun. 2022 May 17.
doi: 10.1002/hep4.2005.
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Doença hepática alcoólica

Incidence and Progression of Alcohol-Associated Liver Disease After Medical Therapy for Alcohol Use Disorder.
Vannier AGL, Shay JES, Fomin V, et al.
JAMA Netw Open. 2022 May 2;5(5):e2213014.
doi: 10.1001/jamanetworkopen.2022.13014.
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Doenças colestáticas e autoimunes

Hepatology, APEF

Noninvasive biomarkers for the diagnosis and management of autoimmune hepatitis.
Harrington C, Krishnan S, Mack CL, et al.
Hepatology. 2022 May 25.
doi: 10.1002/hep.32591.
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journal of hepatology, apef

A phase II, randomized, open-label, 52-week study of seladelpar in patients with primary biliary cholangitis.
Bowlus CL, Galambos MR, Aspinall RJ, et al.
J Hepatol. 2022 Aug;77(2):353-364.
doi: 10.1016/j.jhep.2022.02.033.
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journal of hepatology, apef

Systematic review of response criteria and endpoints in autoimmune hepatitis by the International Autoimmune Hepatitis Group.
Pape S, Snijders RJALM, Gevers TJG, et al.
J Hepatol. 2022 Apr;76(4):841-849.
doi: 10.1016/j.jhep.2021.12.041.
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Falência hepática aguda

CAQ Corner: Acute liver failure management and liver transplantation.
Pan JJ, Fontana RJ.
Liver Transpl. 2022 May 16.
doi: 10.1002/lt.26503.
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nature-review-clinical-oncology, APEF, Fígado

Immune-checkpoint inhibitors: long-term implications of toxicity.
Johnson DB, Nebhan CA, Moslehi JJ, et al.
Nat Rev Clin Oncol. 2022 Apr;19(4):254-267.
doi: 10.1038/s41571-022-00600-w.
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Population screening for liver fibrosis: Toward early diagnosis and intervention for chronic liver diseases.
Ginès P, Castera L, Lammert F, et al..  
Hepatology. 2022 Jan;75(1):219-228. 
doi: 10.1002/hep.32163.     
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Clinical, histological and molecular profiling of different stages of alcohol-related liver disease.
Ventura-Cots M, Argemi J, Jones PD, et al.  
Gut. 2022 Jan 6:gutjnl-2021-324295. 
doi: 10.1136/gutjnl-2021-324295.     
LINK

Ferroptosis and metabolic dysfunction-associated fatty liver disease: is there a link?
Feng G, Byrne CD, Targher G, et al.  
Liver Int. 2022 Jan 10. 
doi: 10.1111/liv.15163.     
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Non-invasive tests accurately stratify patients with NAFLD based on their risk of liver-related events.
Boursier J, Hagström H, Ekstedt M, et al.  
J Hepatology. 2022 
doi: 0.1016/ j.jhep.2021.12.031.     
LINK

2021

Cirrose e Complicações

Infeção

Antibiotic prophylaxis in patients with cirrhosis: Current evidence for clinical practice
Ferrarese A, Passigato N, Cusumano C, et al.
World J Hepatol 2021; 13(8): 840-852.
doi: 10.4254/wjh.v13.i8.840
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Bacterial infections in patients with acute variceal bleeding in the era of antibiotic prophylaxis
Martínez J, Hernández-Gea V, Rodríguez-de-Santiago E, et al.
J Hepatol. 2021 Aug;75(2):342-350.
doi: 10.1016/j.jhep.2021.03.026
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Changes in ascitic fluid polymorphonuclear cell counts impact mortality in patients with spontaneous bacterial peritonites
Santana E, Rezende V, Lima GC, et al.
Clin Gastroenterol Hepatol. 2021 Jul 14:S1542-3565(21)00750-3.
doi: 10.1016/j.cgh.2021.07.019
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Tuberculosis in cirrhosis- A diagnostic and management conundrum
Mishra, Saurabh et al.
Journal of Clinical and Experimental Hepatology. 2021.
doi: 10.1016/j.jceh.2021.09.003
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Encefalopatia Hepática

A Brief History of Hepatic Encephalopathy.
Bass, N.M.   
Clinical Liver Disease. 2021;18: 49-62. 
Doi: 10.1002/cld.1119    
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2021 ISHEN guidelines on animal models of hepatic encephalopathy
DeMorrow S, Cudalbu C, Davies N, Jayakumar AR, Rose CF.
Liver Int. 2021;41(7):1474-1488.
doi:10.1111/liv.14911
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History of Hepatic Encephalopathy is Not a Contraindication to TIPS Placement for Refractory Ascites
Saab S, Zhao M, Asokan I, Yum JJ, Lee EW.
SSRN Electron J. Published online 2020:1-9.
doi:10.2139/ssrn.3702918
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Microbiome Therapeutics for Hepatic Encephalopathy
Bloom P, Tapper EB, Young VB, Lok AS.
J Hepatol. 2021 Aug 25:S0168-8278(21)01998-X.
doi: 10.1016/j.jhep.2021.08.004
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Coagulação e Trombose

Coagulopathy is not predictive of bleeding in patients with acute decompensation of cirrhosis and acute-on-chronic liver failure
Campello E, Zanetto A, Bulato C, et al.
Liver Int. 2021;(May):1-12.
doi:10.1111/liv.1500
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More Pronounced Hypercoagulable State and Hypofibrinolysis in Patients With Cirrhosis With Versus Without HCC
Zanetto A., Elena C., Bulato C. et al.
Hepatology Communications. 2021.
doi: 10.1002/hep4.1781
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Non-malignant portal vein thrombi in patients with cirrhosis consist of intimal fibrosis with or without a fibrin-rich thrombus.
Driever EG, von Meijenfeldt FA, Adelmeijer J, et al.
Hepatology. 2021 Sep 24. 
doi: 10.1002/hep.32169. 
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Comparison of fondaparinux and low molecular weight heparin in the treatment of portal vein thrombosis in cirrhosis
Senzolo M, Piano S, Shalaby S, et al.
Am J Med. 2021;0(0).
doi:10.1016/J.AMJMED.2021.05.013
link

Efficacy and safety of direct oral anticoagulants versus vitamin K antagonist for portal vein thrombosis in cirrhosis: A systematic review and meta-analysis
Koh JH, Liew ZH, Ng GK, et al.
Dig Liver Dis. 2021.
doi:10.1016/j.dld.2021.07.039
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Nutrição

Mistakes in nutrition in chronic liver disease and how to avoid them
Merli M and Lapenna L.
UEG Education 2021; 21: 23–25.
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Micronutrient deficiencies in patients with decompensated liver cirrhosis
Llibre-Nieto G, Lira A, Vergara M, et al.
Nutrients. 2021;13(4):1-14.
doi:10.3390/nu13041249
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Disfunção Hepática e ACLF

Performance of the model for end-stage liver disease score for mortality prediction and the potential role of etiology.
D’Amico G, Maruzzelli L, Airoldi A, et al.    
J Hepatol. 2021 Dec;75(6):1355-1366.
doi: 10.1016/j.jhep.2021.07.018     
linK

MELD 3.0: The Model for End-stage Liver Disease Updated for the Modern Era
Kim WR, Mannalithara A, Heimbach JK, et al.
Gastroenterology. 2021 Sep 2:S0016-5085(21)03469-7.
doi: 10.1053/j.gastro.2021.08.050
link

EASL-CLIF criteria perform better than NACSELD to diagnose and prognosticate ACLF
Li F, Thuluvath PJ.
J Hepatol. Published online 2021.
doi:10.1016/j.jhep.2021.05.033
link

Urinary L-FABP is a promising prognostic biomarker of ACLF and mortality in patients with decompensated cirrhosis
Juanola A, Graupera I, Elia C, et al.
J Hepatol. 2021 Sep 13:S0168-8278(21)02029-8.
doi: 10.1016/j.jhep.2021.08.031
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Granulocyte-Colony Stimulating Factor (G-CSF) to treat acute-on-chronic liver failure, a multicenter randomized trial (GRAFT study)
Engelmann C, Herber A, Franke A, et al.
J Hepatol. Published online 2021.
doi:10.1016/j.jhep.2021.07.033
Link

Cuidados paliativos

Developing Priorities for Palliative Care Research in Advanced Liver Disease: A Multidisciplinary Approach
Patel AA, Woodrell C, Ufere NN, et al.
Hepatol Commun. 2021 Sep;5(9):1469-1480.
doi: 10.1002/hep4.1743
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Integrating Palliative Care in the Management of Patients With Advanced Liver Disease.
Patel A, Ufere NN.   
Clinical Liver Disease. 2020 May 7;15(4):136-140.
doi: 10.1002/cld.936.    
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Palliative Care Always: Hepatology-Virtual Primary Palliative Care Training for Hepatologists.
DeNofrio JC, Verma M, Kosinski AS, et al.   
Hepatol Commun. 2021 Oct 31. 
doi: 10.1002/hep4.1849.   
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Outros

The systemic inflammation hypothesis: Towards a new paradigm of acute decompensation and multiorgan failure in cirrhosis
Arroyo V, Angeli P, Moreau R, et al.
J Hepatol. 2021;74(3):670-685.
doi:10.1016/j.jhep.2020.11.048
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End-stage liver disease: Management of hepatorenal syndrome
Mauro E, Garcia-Olveira L, Gadano A.
Liver Int. 2021;41(S1):119-127.
doi:10.1111/liv.14866
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Diagnosis and Management of Cirrhotic Cardiomyopathy
Kaur H., Premkumar M.
J Clin Exp Hepatol. 2021.  ISSN 0973-6883.
doi: 10.1016/j.jceh.2021.08.016
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Treatment With Simvastatin and Rifaximin Restores the Plasma Metabolomic Profile in Patients With Decompensated Cirrhosis.
Pose E, Solà E, Lozano JJ, et al.  
Hepatol Commun. 2021 Dec 28. 
doi: 10.1002/hep4.1881.    
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Appropriate and Potentially Inappropriate Medication Use in Decompensated Cirrhosis
Thomson MJ, Lok ASF, Tapper EB.
Hepatology. 2021 Jun;73(6):2429-2440.
doi: 10.1002/hep.31548
link

Pharmacotherapy for Weight Loss in Cirrhosis and Liver Transplantation: Translating the Data and Underused Potential
Brown SA, Izzy M, Watt KD.
Hepatology. 2021;73(5):2051-2062.
doi:10.1002/hep.31595
link

Mortality Trends in Chronic Liver Disease and Cirrhosis in the United States, Before and During COVID-19 Pandemic.
Kim D, Bonham CA, Konyn P, et al.  
Clin Gastroenterol Hepatol. 2021 Dec;19(12):2664-2666.e2. 
doi: 10.1016/j.cgh.2021.07.009.  
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Management of pregnancy in women with cirrhosis.
Rahim MN, Pirani T, Williamson C, et al.  
United European Gastroenterol J. 
doi: 10.1177/2050640620977034.     
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Risk Prediction Models for Postoperative Decompensation and Infection in Patients With Cirrhosis: A Veterans Affairs Cohort Study
Mahmud N, Fricker Z, Lewis JD, Taddei TH, Goldberg DS, Kaplan DE.
Clin Gastroenterol Hepatol. 2021 Jul 8:S1542-3565(21)00721-7.
doi: 10.1016/j.cgh.2021.06.050. Epub ahead of print.
link

Hipertensão portal

Portal pressure measurement: Have we come full circle?
Bazarbashi AN, Ryou M.
Gastrointest Endosc. 2021 Mar;93(3):573-576.
doi: 10.1016/j.gie.2020.08.007. PMID: 33583516
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North American Practice-Based Recommendations for Transjugular Intrahepatic Portosystemic Shunts in Portal Hypertension
Zhou H, Chen R, Wang J, et al.
Clin Gastroenterol Hepatol. 2021 Jul 15:S1542-3565(21)00749-7.
doi:10.1016/j.cgh.2021.07.018
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Low Serum Cholinesterase Identifies Patients With Worse Outcome and Increased Mortality After TIPS.
Stockhoff L, Muellner-Bucsics T, Markova AA, et al.
Hepatol Commun. 2021 Sep 28. 
doi: 10.1002/hep4.1829. 
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Friend or Foe? Spontaneous Portosystemic Shunts in Cirrhosis-Current Understanding and Future Prospects
Rajesh S, Philips CA, Ahamed R, et al.
Gastroenterol Hepatol. 2021 Aug 12;2021:8795115.
doi: 10.1155/2021/8795115
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Outcomes After TIPS for Ascites and Variceal Bleeding in a Contemporary Era—An ALTA Group Study
Boike JR, Mazumder NR, Kolli KP et al.
Am J Gastroenterol. 2021 Jun 23.
doi: 10.14309/ajg.0000000000001357
link

The Value of Liver and Spleen Stiffness for Evaluation of Portal Hypertension in Compensated Cirrhosis.
Reiberger T.  
Hepatol Commun. 2021 Dec 14. 
doi: 10.1002/hep4.1855.     
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Carcinoma Hepatocelular e Colangiocarcinoma

Preneoplastic lesions in the liver: Molecular insights and relevance for clinical practice.
Desjonqueres E, Campani C, Marra F, et al.  
Liver Int. 2022 Jan 4. 
doi: 10.1111/liv.15152.   
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Diagnostic Criteria and LI-RADS for Hepatocellular Carcinoma
Lee YT, Wang JJ, Zhu Y, Agopian VG, Tseng HR, Yang JD.
Clin Liver Dis (Hoboken). 2021 Aug 5;17(6):409-413.
doi: 10.1002/cld.1075
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BCLC strategy for prognosis prediction and treatment recommendation Barcelona Clinic Liver Cancer (BCLC) staging system. The 2022 update.
Reig M, Forner A, Rimola J, et al.   
J Hepatol. 2021 Nov 18:S0168-8278(21)02223-6. 
doi: 10.1016/j.jhep.2021.11.018.    
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Impact of corticosteroid therapy on the outcomes of hepatocellular carcinoma treated with immune checkpoint inhibitor therapy
Pinato DJ, Kaseb A, Wang Y, et al.
J Immunother Cancer. 2020 Oct;8(2):e000726.
doi: 10.1136/jitc-2020-000726
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Society for Immunotherapy of Cancer (SITC) clinical practice guideline on immunotherapy for the treatment of hepatocellular carcinoma
Greten TF, Abou-Alfa GK, Cheng AL, et al.
J Immunother Cancer. 2021 Sep;9(9):e002794.
doi: 10.1136/jitc-2021-002794
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NASH limits anti-tumour surveillance in immunotherapy-treated HCC.
Pfister D, Núñez NG, Pinyol R, et al.  
Nature. 2021 Apr;592(7854):450-456. 
doi: 10.1038/s41586-021-03362-0.    
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Prognosis of patients with hepatocellular carcinoma treated with immunotherapy – development and validation of the CRAFITY score. 
Scheiner B, Pomej K, Kirstein MM, et al.
J Hepatol. 2021 Oct 11:S0168-8278(21)02100-0.
doi: 0.1016/j.jhep.2021.09.035
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Systemic treatment of hepatocellular carcinoma. An EASL position paper
Bruix J, Chan SL, Galle PR, et al.
J Hepatol. 2021 Jul 10:S0168-8278(21)01903-6.
doi:10.1016/j.jhep.2021.07.004
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Liver Transplantation Criteria for Hepatocellular Carcinoma, Including Posttransplant Management
Mehta N.
Clin Liver Dis. 2021;17(5):332-336.
doi:10.1002/cld.1054
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Safety , Efficacy , and Pharmacodynamics of Tremelimumab Plus Durvalumab for Patients With Unresectable Hepatocellular Carcinoma : Randomized Expansion of a Phase I / II Study abstract
Kelley RK, Sangro B, Harris W et al.
J Clin Oncol. 2021 Jul 22:JCO2003555.
doi:10.1200/JCO.20.03555
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Early diarrhoea under sorafenib as a marker to consider the early migration to second ‐ line drugs
González ÁD, Sapena V, Zamparelli MS, et al.
United European Gastroenterol J. 2021;9(6):655-61.
doi:10.1002/ueg2.12111
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Down-staging Outcomes for Hepatocellular Carcinoma: Results from the Multicenter Evaluation of Reduction in Tumor Size before Liver Transplantation (MERITS-LT) Consortium
Mehta, N., Frenette, C., Tabrizian, P., et al.
Gastroenterology. 2021;0(0).
doi:10.1053/J.GASTRO.2021.07.033
Link

Multimarker Panels for Detection of Early Stage Hepatocellular Carcinoma: A Prospective, Multicenter, Case-Control Study.
Piratvisuth T, Tanwandee T, Thongsawat S, et al.
Hepatol Commun. 2021 Nov 19.
doi: 10.1002/hep4.1847.    
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Cholangiocarcinoma
Brindley PJ, Bachini M, Ilyas SI, et al.
Nat Rev Dis Primers. 2021 Sep 9;7(1):65.
doi: 10.1038/s41572-021-00300-2
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Immune Checkpoint Inhibitors: The Emerging Cornerstone in Cholangiocarcinoma Therapy?
Gutiérrez-Larrañaga M, González-López E, Roa-Bautista A, et al.
Liver Cancer 2021. 
doi: 10.1159/000518104 
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Pre-Transplant Alpha-Fetoprotein > 25.5 and Its Dynamic on Waitlist Are Predictors of HCC Recurrence after Liver Transplantation for Patients Meeting Milan Criteria.
Magro B, Pinelli D, De Giorgio M, et al.  
Cancers (Basel). 2021 Nov 27;13(23):5976. 
doi: 10.3390/cancers13235976.     
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Hepatites Virais

Viral Hepatitis in Pregnancy: An Update on Screening, Diagnosis, and Management
Sanghi, V. and Lindenmeyer, C.C.
Clinical Liver Disease. 2021. 18: 7-13.
doi: 10.1002/cld.1079
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Risks and Benefits of Discontinuation of Nucleos(t)ide Analogue Treatment: A Treatment Concept for Patients With HBeAg‐Negative Chronic Hepatitis B
Bömmel F, Berg T.
Hepatol Commun. 2021;0(0):1-17.
doi:10.1002/hep4.1708
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Decreases in Hepatitis C Testing and Treatment During the COVID-19 Pandemic
Kaufman HW, Bull-Otterson L, Meyer WA 3rd, et al.
Am J Prev Med. 2021 Sep;61(3):369-376.
doi: 10.1016/j.amepre.2021.03.011
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Decreasing VWF-levels upon NSBB-therapy indicate a decreased risk of further decompensation, ACLF, and death
Jachs M, Hartl L, Simbrunner B, et al.
Clin Gastroenterol Hepatol. 2021;(August).
doi:10.1016/j.cgh.2021.07.012
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Risk of transfusion-transmitted hepatitis E virus infection from pool-tested platelets and plasma.
Cordes AK, Goudeva L, Lütgehetmann M, et al.  
J Hepatol. 2022 Jan;76(1):46-52. 
doi: 10.1016/j.jhep.2021.08.018.    
LINK

Fígado Gordo Não Alcoólico

Poor Awareness of Liver Disease Among Adults With NAFLD in the United States
Alqahtani SA, Paik JM, Biswas R, Arshad T, Henry L, Younossi ZM.
Hepatol Commun. 2021;0(0):1-3.
doi:10.1002/hep4.1765
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NAFLD Cirrhosis Is Rising Among Childbearing Women and Is the Most Common Cause of Cirrhosis in Pregnancy
Sarkar M, Djerboua M, Flemming JA.
Clin Gastroenterol Hepatol. Published online 2021.
doi:10.1016/j.cgh.2021.01.022
Link

Maternal obesity increases the risk and severity of NAFLD in offspring
Hannes Sharma HB, Panigrahi S, Sarmah AK, Dubey BK.
J Hepatol. 2021 Jul 10:S0168-8278(21)01899-7.
doi:10.1016/j.jhep.2021.06.045
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Non-alcoholic fatty liver disease: A patient guideline
Francque S, Marchesini G, Kautz A, et al.
JHEP Reports. 2021.
doi: 10.1016/j.jhepr.2021.100322
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Imaging biomarkers of NAFLD, NASH, and fibrosis
Ajmera V, Loomba R.
Mol Metab. 2021;50(January):1-7.
doi:10.1016/j.molmet.2021.101167
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Magnetic resonance elastography for the clinical risk assessment of fibrosis, cirrhosis, and portal hypertension in patients with NAFLD
Natarajan Y., Loomba R.
J Clin Exp Hepatol. 2021 Aug.
Doi: 10.1016/j.jceh.2021.08.002
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Predicting Liver-Related Outcomes in People With Nonalcoholic Fatty Liver Disease: The Prognostic Value of Noninvasive Fibrosis Tests.
Johnson AL, Hayward KL, Patel P, et al.  
Hepatol Commun. 2021 Nov 15. 
doi: 10.1002/hep4.1852.  
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Clinical Care Pathway for the Risk Stratification and Management of Patients With Nonalcoholic Fatty Liver Disease.
Kanwal F, Shubrook JH, Adams LA, et al.  
Gastroenterology. 2021 Nov;161(5):1657-1669. 
doi: 10.1053/j.gastro.2021.07.049.    
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Weight-loss-independent benefits of exercise on liver steatosis and stiffness in Japanese men with NAFLD
Oh S, Tsujimoto T, Kim B, et al.
JHEP Reports. 2021;3(3):100253.
doi:10.1016/j.jhepr.2021.100253
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Obeticholic Acid for the Treatment of Nonalcoholic Steatohepatitis
Ratziu V.
Clinical Liver Disease. 2021;17(6):398-400.
doi:10.1002/cld.1076
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Rational HCC screening approaches for patients with NAFLD.
Singal AG, El-Serag HB.  
J Hepatol. 2022 Jan;76(1):195-201. 
doi: 10.1016/j.jhep.2021.08.028.    
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Doença Hepática Alcoólica

Global burden of cancer in 2020 attributable to alcohol consumption: a population-based study
Rumgay H, Shield K, Hadrien Charvat, et al.
Lancet Oncol. 2021 Jul 13:S1470-2045(21)00279-5.
doi:10.1016/S1470-2045(21)00279-5
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Socioeconomic Inequalities in the Incidence of Alcohol-Related Liver Disease: a Nationwide Danish Study
Askgaard G, Fleming K, Kraglund F, et al.
Hepatology. 2020;72(1):191A-192A.
doi:10.1016/j.lanepe.2021.10017
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Effect of Increased Alcohol Consumption During COVID-19 Pandemic on Alcohol-related Liver Disease: A Modeling Study.
Julien J, Ayer T, Tapper EB, et al.  
Hepatol Commun. 2021 Dec 14. 
doi: 10.1002/hep.32272.      
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Simultaneous Metabolic and Alcohol-associated Fatty Liver Disease (SMAFLD) and Simultaneous Metabolic and Alcohol-associated Steatohepatitis (SMASH)
Senussi NH, McCarthy DM.
Ann Hepatol. 2021 Sep-Oct;24:100526.
doi: 10.1016/j.aohep.2021.100526
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Diagnosis and Treatment of Alcohol-Associated Liver Disease: A Review
Singal AK, Mathurin P.
JAMA. 2021;326(2):165–176.
doi:10.1001/jama.2021.7683
link

Identification of optimal therapeutic window for steroid use in severe alcohol-associated hepatitis: A worldwide study
Arab JP, Díaz LA, Baeza N et al.
J Hepatol. 2021 Jun 21:S0168-8278(21)00439-6.
doi: 10.1016/j.jhep.2021.06.019
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Evaluation of Early vs Standard Liver Transplant for Alcohol-Associated Liver Disease
Herrick-Reynolds, K. M., Punchhi, G., Greenberg, R. S., et al.
JAMA Surg. Published online August 11, 2021.
doi:10.1001/JAMASURG.2021.3748
Link

Alcohol and Acute-on-Chronic Liver Failure
Ballester MP, Sittner R, Jalan R.  
Journal of Clinical and Experimental Hepatology, 2021. ISSN 0973-6883. 
Doi: 10.1016/j.jceh.2021.12.010.    
LINK

Liver biopsy in patients with alcohol-associated liver disease with acute on chronicliver failure
Jophlin L, Singal A.K.
Journal of Clinical and Experimental Hepatology. 2021, ISSN 0973-6883.
doi:10.1016/j.jceh.2021.08.009
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Joining the Fight: Enhancing Alcohol Treatment Education in Hepatology.
Winters AC, Aby ES, Fix OK, et al.  
Clin Liver Dis (Hoboken). 2021 Nov 20;18(5):225-229. 
doi: 10.1002/cld.1127.    
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Doenças Colestásticas e Autoimunes

Distinct prognostic value of different portal hypertension-associated features in patients with primary biliary cholangitis.
Burghart L, Halilbasic E, Schwabl P, et al.  
J Gastroenterol. 2021 Dec 11. 
doi: 10.1007/s00535-021-01839-3  
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Obeticholic Acid and Fibrates in Primary Biliary Cholangitis: Comparative Effects in a Multicentric Observational Study
Reig A, Álvarez-Navascués C, Vergara M et al.
Am J Gastroenterol. 2021 Jun 23.
doi: 10.14309/ajg.0000000000001343
link

Proof-of-concept study to evaluate the safety and efficacy of saroglitazar in patients with primary biliary cholangitis
Vuppalanchi R, Caldwell SH, Pyrsopoulos N, et al.
J Hepatol. 2021 Sep 3:S0168-8278(21)02023-7.
doi: 10.1016/j.jhep.2021.08.025
link

Emerging drugs for the treatment of primary sclerosing cholangitis.
Abbas N, Quraishi MN, Trivedi P  
ScienceDirect Pharmacology Curr Opin Pharmacol. 2021 Dec 8;62:23-35. 
doi: 10.1016/j.coph.2021.11.003.   
LINK

Histological activity despite normal ALT and IgG serum levels in patients with autoimmune hepatitis and cirrhosis
Laschtowitz A, Zachou K, Lygoura V, et al.
JHEP Reports. 2021;3(4):100321.
doi:10.1016/j.jhepr.2021.100321
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Autoimmune hepatitis in patients aged 70 years or older: Disease characteristics, treatment response and outcome
Dalekos GN, Azariadis K, Lygoura V, et al.
Liver Int. 2021;41(7):1592-1599.
doi:10.1111/LIV.14900
link

Hepatic Manifestations of Immunoglobulin G4-Related Disease
Sharzehi, K.
Clinical Liver Disease. 2021.
doi: 10.1002/cld.1087
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Doenças Genéticas

Wilson’s disease: Revisiting an old friend
Lucena-Valera A, Perez-Palacios D, Muñoz-Hernandez R, et al.
World J Hepatol. 2021 Jun 27;13(6):634-649.
doi: 10.4254/wjh.v13.i6.634
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Direct Measurement of ATP7B Peptides Is Highly Effective in the Diagnosis of Wilson Disease
Collins CJ, Yi F, Dayuha R, et al.
Gastroenterology. 2021;160(7):2367-2382.e1.
doi:10.1053/j.gastro.2021.02.052
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Hemochromatosis classification: update and recommendations by the BIOIRON Society.
Girelli D, Busti F, Brissot P, Cabantchik I, Muckenthaler MU, Porto G. Blood. 2021 Oct 3:blood.2021011338. 
doi: 10.1182/blood.2021011338.    
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Appropriate Clinical Genetic Testing of Hemochromatosis Type 2-4, Including Ferroportin Disease
Kowdley DS, Kowdley KV.
Appl Clin Genet. 2021 Aug 12;14:353-361.
doi: 10.2147/TACG.S269622
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Alpha-1 antitrypsin deficiency: a re-surfacing adult liver disorder.
Fromme M, Schneider CV, Trautwein C, Brunetti-Pierri N, Strnad P J Hepatol. 2021 Nov 27:S0168-8278(21)02227-3.
doi: 10.1016/j.jhep.2021.11.022.     
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Genetic Disorders of Bile Acid Transport
Henkel AS.
Clin Liver Dis. 2021;0(0):1-6.
doi:10.1002/cld.1132
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Estrogens in Polycystic Liver Disease: A Target for Future Therapies?
Aapkes SE, Bernts LHP, Barten TRM, et al.
Liver Int 2021.
doi:10.1111/liv.14986
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Palliative Care Always: Hepatology-Virtual Primary Palliative Care Training for Hepatologists.
DeNofrio JC, Verma M, Kosinski AS, et al. 
Hepatol Commun. 2021 Oct 31. 
doi: 10.1002/hep4.1849.  
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Hepatic Manifestations of Urea Cycle Disorders
Strong, A., Gold, J., Gold, N.B., Yudkoff, M.
Clinical Liver Disease. 2021.
doi: 10.1002/cld.1115
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Outros

Abnormal liver enzymes: A review for clinicians.
Kalas MA, Chavez L, Leon M, et al.  
World J Hepatol. 2021 Nov 27;13(11):1688-1698. 
doi: 10.4254/wjh.v13.i11.1688.    
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Gamma-Glutamyl Transferase (γ-GT) – an old dog with new tricks?
Brennan PN, Dillon JF, Tapper EB.  
Liver Int. 2022 Jan;42(1):9-15. 
doi: 10.1111/liv.15099.    
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COVID‐19 ‐Related Downscaling of In‐Hospital Liver Care Decreased Patient Satisfaction and Increased Liver‐Related Mortality
Hartl L, Semmler G, Hofer BS, et al.
Hepatol Commun. 2021;0(0):1-16.
doi:10.1002/hep4.1758
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Hepatic Venous Outflow Tract Obstruction: Causes, Natural History, and Treatment.
Gamanagatti, S. and Hemachandran, N.  
Clinical Liver Disease. 2021; 18: 117-121. 
Doi: 10.1002/cld.1126   
LINK

Liver abscess: Complications and Treatment
Sharma S, Ahuja V.
Clinical Liver Disease 2021;0(0):1-5.
doi:10.1002/cld.1128
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Clinical management of patients with drug‐induced liver injury (DILI)
Björnsson ES.
United Eur Gastroenterol J. 2021;(March):1-6.
doi:10.1002/ueg2.12113
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When and how to use direct oral anticoagulants in patients with advanced chronic liver disease?
Maria C De, Galante A, Fasoli A, Gottardi A De.
ScienceDirect Pharmacology Curr Opin Pharmacol. 2021;60:111-116.
doi:10.1016/j.coph.2021.07.006
link

Predicting portal thrombosis in cirrhosis: A prospective study of clinical, ultrasonographic and hemostatic factors
Turon F, Driever EG, Baiges A, et al.
J Hepatol. Published online 2021.
doi:10.1016/j.jhep.2021.07.020
link

2020

Hepatitis C-related cirrhosis will be a marginal cause of hospital admissions by 2025
Rodríguez-Tajes S, Pocurull A, Castillo J, et al.
J Hepatol. 2020;73(6):1360-1367
doi:10.1016/j.jhep.2020.07.018
link

A randomised, double-blind, placebo-controlled, multi-centre, dose-range, proof-of-concept, 24-week treatment study of lanifibranor in adult subjects with non-alcoholic steatohepatitis: Design of the NATIVE study.
Sven M. F, Pierre B, Manal F. A, et al.
Contemp Clin Trials 2020;98(August):106170.
doi:10.1016/j.cct.2020.106170
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Long-term outcomes in patients with decompensated alcohol-related liver disease, steatohepatitis and Maddrey’s discriminant function <32
Degré D, Stauber RE, Englebert G, et al.
J Hepatol. 2020;72(4):636-642.
doi:10.1016/j.jhep.2019.12.023
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Development of an RNAi therapeutic for alpha-1-antitrypsin liver disease
Wooddell CI, Blomenkamp K, Peterson RM, et al.
JCI Insight. 2020;5(12):1-19.
doi:10.1172/jci.insight.135348
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