EASL Clinical Practice Guidelines: Wilson’s disease | 2012 EASL

Doenças Genéticas 2012

Summary
This Clinical Practice Guideline (CPG) has been developed to
assist physicians and other healthcare providers in the diagnosis
and management of patients with Wilson’s disease. The goal is to
describe a number of generally accepted approaches for diagnosis, prevention, and treatment of Wilson’s disease. Recommendations are based on a systematic literature review in the Medline
(PubMed version), Embase (Dialog version), and the Cochrane
Library databases using entries from 1966 to 2011. The Grades
of Recommendation, Assessment, Development, and Evaluation
(GRADE) system used in other EASL CPGs was used and set
against the somewhat different grading system used in the
AASLD guidelines (Table 1A and B). Unfortunately, there is not
a single randomized controlled trial conducted in Wilson’s disease which has an optimal design. Thus, it is impossible to assign
a high or even a moderate quality of evidence to any of the questions dealt with in these guidelines. The evaluation is mostly
based on large case series which have been reported within the
last decades.
2011 European Association for the Study of the Liver. Published
by Elsevier B.V. All rights reserved.

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