EASL Clinical Practice Guidelines: Management of hepatitis C virus infection | 2011 EASL

Hepatites Virais 2011

  1. Introduction
    Hepatitis C virus (HCV) infection is one of the main causes of
    chronic liver disease worldwide [1]. The long-term hepatic
    impact of HCV infection is highly variable, from minimal changes
    to chronic hepatitis, extensive fibrosis, and cirrhosis with or without hepatocellular carcinoma (HCC). The number of chronically
    infected persons worldwide may exceed 200 million, but most
    of them have no knowledge of their infection or of the ensuing
    hepatic condition. Clinical care for patients with HCV-related
    liver disease has advanced considerably during the last two decades, as a result of growing knowledge about the mechanisms of
    the disease, remarkable developments in diagnostic procedures,
    and advances in therapeutic and preventative approaches. Still,
    various aspects are not yet completely resolved.
    These EASL Clinical Practice Guidelines (CPGs) are intended to
    assist physicians and other healthcare providers, as well as patients
    and interested individuals, in the clinical decision-making process
    by describing optimal management of patients with acute and
    chronic HCV infections. These guidelines apply to therapies that
    are approved at the time of their publication. Several new therapeutic options have completed phase III development for patients
    infected with HCV genotype 1 and are currently awaiting licensing
    and approval in Europe and the United States. Therefore, the EASL
    CPGs on the management of HCV infection will be updated on a
    regular basis upon approval of additional novel therapies.
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